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    Prograf suppresses immune system and is used to prevent organ rejection after transplantation of heart, kidney, small bowel, bone marrow. Its active component is anhydrous tacrolimus. The drug binds to cytosolic protein (FKBP 12) and inhibits calcineurin hereby suppressing T-cell dependent immune response of the organism, formation of cytotoxic lymphocytes, proliferation of B cells depending on T-helpers, and formation of interleukin-2, -3 and ?-interferon.


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